Science

1️⃣ Synergistic Gut Support – How It Works

SuperAkki™ is a next-generation gut health supplement formulated around one central idea: the gut works as a system, not in isolated parts. That’s why each ingredient in SuperAkki™ is carefully selected — not just for its individual benefits, but for how it interacts with the others to create a synergistic effect. Together, they support gut lining integrity, microbial balance, and digestive comfort in a way that is far greater than the sum of their parts.*

🧱 A Foundation of Support: Gut Lining Integrity

The intestinal lining helps manage the exchange of nutrients and interacts closely with the gut microbiota. Over time, lifestyle and dietary factors may influence the gut environment.*

SuperAkki™ includes N-Acetyl-D-Glucosamine (NAG), an amino sugar that serves as a structural component of mucosal tissue. NAG helps support the natural production of glycosaminoglycans — compounds involved in maintaining the mucous layer of the gut. This layer plays a role in supporting the gut lining and creating favorable conditions for beneficial bacteria.*

By providing targeted support for gut lining health, NAG may help reinforce the base for broader digestive wellness. This sets the stage for the other ingredients in SuperAkki™ to work in synergy.*

⚖️ Microbial Balance: Feeding the Right Ecosystem

A healthy gut microbiome functions like a well-balanced ecosystem — when beneficial bacteria are supported, overall microbial harmony can improve. Organic Agave Inulin is a low-fermentable prebiotic fiber that helps nourish helpful microbes like Bifidobacteria and Lactobacillus.*

Unlike some fibers that may cause gas or bloating, agave-derived inulin is generally well-tolerated and may gently encourage microbial diversity. By supporting beneficial bacteria, inulin contributes to the natural production of short-chain fatty acids (SCFAs), such as butyrate — compounds known to play a role in colon health and digestive comfort.*

Even more, inulin helps establish a favorable environment for SuperAkki™’s other ingredients to work in harmony.*

🧪 The Postbiotic Edge: Pasteurized Akkermansia

Akkermansia muciniphila is an emerging focus in gut health research, valued for its association with gut lining function and microbial diversity.* This unique microbe naturally resides in the mucus layer of the intestines.*

SuperAkki™ features the pasteurized Akk11 strain — a shelf-stable, non-live form that doesn’t require refrigeration. This inactivated form allows convenient delivery while retaining key biological properties studied in peer-reviewed trials.*

When combined with other ingredients in SuperAkki™, Akkermansia plays a complementary role:

NAG supports the mucosal environment where Akkermansia typically resides*
Inulin helps nourish beneficial microbes that coexist within a diverse microbiome*
Lactoferrin supports microbial balance, rounding out a multi-pronged approach to digestive support*

🛡️ Gut Environment & Resilience: The Role of Lactoferrin

The gut is constantly adapting to everyday challenges — from changes in diet to environmental stressors. Lactoferrin, a natural glycoprotein found in milk, helps support a more balanced and resilient gut environment.*

It works by binding to free iron, a nutrient many unwanted microbes depend on. By modulating available iron levels, lactoferrin helps maintain a microbial environment that favors beneficial species.* It also supports mucosal balance and gut-associated immune function — especially when combined with inulin, which helps create a favorable prebiotic setting for microbial harmony.*

🧠 The Synergy in Action

What makes SuperAkki™ unique isn’t just its ingredients — it’s how they work together:

NAG supports the gut lining’s natural structure*
Akkermansia contributes to microbial diversity*
Inulin nourishes beneficial flora and supports Akkermansia’s environment*
Lactoferrin promotes microbial balance and mucosal support*

The result is a science-inspired formula that supports gut health from multiple angles — including gut lining integrity, microbial balance, and digestive comfort — all working together in harmony.*

🟦 N-Acetyl-D-Glucosamine (NAG)

NAG is an amino sugar naturally found in the body, especially in mucosal tissues like the gut lining. It plays a supportive role in the production of glycoproteins that help form the mucus layer — the protective barrier between the gut wall and the contents of the digestive tract.*

In supplement form, NAG doesn’t “repair” or “heal,” but may help support the gut’s structural environment and barrier function.* This makes it useful for maintaining digestive comfort and regularity — especially when the gut is under stress due to diet, low fiber intake, or other everyday factors.*

🟩 Lactoferrin

Lactoferrin is a glycoprotein naturally present in human and bovine milk. It helps maintain microbial balance in the gut by binding to iron — an essential mineral that some undesirable microbes rely on for growth. By managing iron availability, lactoferrin creates a more favorable setting for beneficial species to thrive.*

It’s also known to support mucosal surface health and help maintain gut immune resilience, making it ideal for supporting gut stability during times of stress.* Combined with inulin, it can contribute to a more well-rounded, prebiotic-friendly environment.*

🟨 Organic Agave Inulin

Inulin is a plant-based prebiotic fiber that nourishes beneficial bacteria in the gut, such as Bifidobacteria and Lactobacillus.* As these microbes ferment inulin, they produce short-chain fatty acids (SCFAs) — compounds known for their positive role in colon health and gut comfort.*

The agave-derived inulin used in SuperAkki™ is chosen for its low fermentation profile, making it gentle on the stomach and less likely to cause gas or bloating.* It also complements Akkermansia by helping establish a gut environment conducive to microbial diversity.*

🟥 Pasteurized Akkermansia muciniphila (Akk11 Strain)

Akkermansia muciniphila is a postbiotic microbe naturally present in the mucus layer of a healthy gut. It’s associated with gut lining structure and microbial diversity, making it a valuable addition to any gut support routine.*

SuperAkki™ uses a pasteurized (non-live) version of the Akk11 strain — shelf-stable and convenient for daily use without refrigeration. This form has been studied in peer-reviewed research for its ability to maintain beneficial activity while offering greater stability than live strains.*

In SuperAkki™, pasteurized Akkermansia complements the formula by interacting positively with NAG, inulin, and lactoferrin to help support a more balanced and resilient gut environment.*

Supplementation with pasteurized Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study. Nat Med. 2019;25(7):1096–1103.
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci. 2013;110(22):9066–71.
Mucosal barrier in the gut. Gastroenterol Clin North Am. 2011;40(4):685–699.
Prebiotics in the gastrointestinal tract. Aliment Pharmacol Ther. 2006;24(5):701–714.
Lactoferrin: a multifunctional glycoprotein of the immune system. Adv Exp Med Biol. 2009;606:1–15.
Microbes inside—from diversity to function: the case of Akkermansia. ISME J. 2012;6(8):1449–58.